How does Intention to Treat (ITT) analysis compare to other methods?
To understand ITT analysis more deeply, let’s compare it with other common methods of analysis: per-protocol (PP) and as-treated (AT). 1. Intention-to-Treat (ITT) Analysis Definition: Includes all participants as originally randomized, regardless of adherence to the protocol. Key Characteristics: Preserves the benefits of randomization. Reflects the real-world effectiveness of the intervention. Handles deviations such as noncompliance or dropout by including all participants in their assigned groups. Strengths: Minimizes bias and maintains the initial comparability of groups. Provides conservative estimates of…